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KMID : 0043319920150010091
Archives of Pharmacal Research
1992 Volume.15 No. 1 p.91 ~ p.94
Ketoketene gem-Dithiols: Synthesis of Some Sulphur Heterocycles as Antimicrobial Agents
Zayed SE
Hussin IA
Abstract
A convenient method for the preparation of N-aryl thiazolines 4a,b, 2,2-dichlorothiophene 5, thiazolinones 6 and 8, and 2,6-dihydrothiopyran 2-thione 9 derivatives is described. This depends on interaction of 3,3-dimercapto-1-(4-biphenyl)-2-propen-1-one 1 with dichloroethane, amines, trichloroacetylchloride, chloroacetamide, ethylene oxide and epichlorohydrin. Antimicrobial activity of the obtained products was studied.
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